Jacobson V, Nielsen C, Buch D, Shields W D, Christenson P, Zachau-Christiansen B, Cherry J D
Department of Neurology, UCLA School of Medicine.
Tokai J Exp Clin Med. 1988;13 Suppl:137-42.
A change in the pertussis immunization schedule in Denmark allowed a retrospective study examining the relationship of the time of onset of selected neurologic disorders with the time of pertussis immunization in two core cohorts of children. Records of 2,199 children with febrile seizures were reviewed and a significant association between first febrile seizures and the scheduled age of pertussis immunization was noted (p = 0.004). The occurrence of epilepsy and CNS infections did not appear to be related to the time of pertussis immunization.
丹麦百日咳免疫接种计划的一项变更使得一项回顾性研究得以开展，该研究调查了两组核心儿童队列中特定神经系统疾病的发病时间与百日咳免疫接种时间之间的关系。研究人员查阅了2199例热性惊厥儿童的记录，并发现首次热性惊厥与百日咳免疫接种的预定年龄之间存在显著关联（p = 0.004）。癫痫和中枢神经系统感染的发生似乎与百日咳免疫接种时间无关。
