Ida Keila K, Fantoni Denise T, Ibiapina Bruna T, Souto Maria-Teresa M R, Zoppa André L V, Silva Luis Claudio L C, Ambrósio Aline M
Laboratório de Investigação Médica LIM-08, Anestesiologia, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, Brazil.
Vet Surg. 2013 Oct;42(7):877-84. doi: 10.1111/j.1532-950X.2013.12050.x. Epub 2013 Sep 3.
To evaluate equine cardiopulmonary function and recovery quality after administration of 0.25 or 0.50 mg/kg xylazine intravenously (IV) during recovery.
Randomized, blinded, prospective, clinical study.
Horses (n = 20).
During recovery after 3 hours of isoflurane anesthesia for arthroscopic surgery, horses were administered either 0.25 mg/kg (G25, n = 10) or 0.50 mg/kg (G50, n = 10) xylazine intravenously. Vital signs and arterial blood samples were obtained during recovery before sedation (baseline), 5, 10, 20, 30, and 45 minutes after xylazine and 30 minutes after standing. The quality of recovery scores ranged from 10 to 72 (10 = best, 72 = worst).
G25 horses recovered faster (mean ± SD, 33 ± 5 min) than G50 horses (50 ± 7 min, P < .0001). Mean maximal decrease in arterial oxygen tension was 55 ± 11 mmHg in G25 (at 10 minutes; P < .05) and 54 ± 7 mmHg in G50 (at 20 minutes; P < .01). G25 group had a total recovery score (23 [range 18-29]) and number of attempts to stand (4 ± 2) greater than the G50 group (18 [10-23] and 1 ± 1, respectively; P < .001).
Both doses of xylazine promoted a moderate and transient hypoxemia during recovery; however, the 0.5 mg/kg dose produced a longer and improved quality of recovery from anesthesia.
评估在恢复过程中静脉注射0.25或0.50mg/kg赛拉嗪后马的心肺功能及恢复质量。
随机、双盲、前瞻性临床研究。
马（n = 20）。
在关节镜手术异氟烷麻醉3小时后的恢复过程中，给马静脉注射0.25mg/kg（G25组，n = 10）或0.50mg/kg（G50组，n = 10）赛拉嗪。在恢复过程中，于镇静前（基线）、注射赛拉嗪后5、10、20、30和45分钟以及站立后30分钟采集生命体征和动脉血样本。恢复质量评分范围为10至72分（10分表示最佳，72分表示最差）。
G25组马恢复得比G50组马更快（均值±标准差，33±5分钟比50±7分钟，P <.0001）。G25组动脉血氧分压的平均最大降幅在10分钟时为55±11mmHg（P <.05），G50组在20分钟时为54±7mmHg（P <.01）。G25组的总恢复评分（23[范围18 - 29]）和站立尝试次数（4±2）高于G50组（分别为18[10 - 23]和1±1；P <.001）。
两种剂量的赛拉嗪在恢复过程中均引发了中度且短暂的低氧血症；然而，0.5mg/kg剂量产生了更长且更好的麻醉恢复质量。
