Schoeffler A, Waton J, Latarche C, Poreaux C, Cuny J-F, Schmutz J-L, Barbaud A
Service de dermatologie, hôpitaux de Brabois, CHU de Nancy, bâtiment des spécialités médicales Philippe-Canton, rue du Morvan, 54511 Vandœuvre-lès-Nancy cedex, France.
Ann Dermatol Venereol. 2013 Aug-Sep;140(8-9):499-509. doi: 10.1016/j.annder.2013.02.012. Epub 2013 Apr 6.
Periodically updated, the European baseline series (EBS), first introduced in France in 1980, is an indispensable tool for the exploration of contact allergy. The aim of our study was to describe the prevalence of contact sensitization in a French centre between 1981 and 2011 to determine whether certain allergens may be deleted from the current BSE.
PATIENTS, MATERIALS AND METHODS: A retrospective study was conducted in a department of dermatology-allergology to analyse the results of all EBS tests performed every 10 years, from 1981 to 2001, and annually from 2007 to 2011. Some added allergens, introduced in 2010, were also studied. Changes in allergen positivity were analysed using a Cochran-Armitage test.
Among the 4551 patients included for the 8-year period studied, the prevalence of positivity was 42.91%. The most common allergens in the general population were nickel sulphate (17.25%), with a constantly increasing prevalence, Myroxylon pereirae (10.68%), fragrance mix I (8.11%), cobalt chloride (6.99%) and chromium (6.33%). The least frequent sensitizations, with a decreasing prevalence, were found with clioquinol (0.25%), primin (0.54%) and benzocaine (0.55%).
Due to modifications in exposure to allergens, the incidence of contact sensitization can change, but nickel sulphate sensitization is increasing despite recent European directives. Allergens with less than 1% of positive results could be withdrawn from the EBS, with benzalkonium chloride, methylisothiazolinone and lavender absolute being added.
欧洲基线系列（EBS）于1980年首次在法国推出，定期更新，是探索接触性过敏的不可或缺的工具。我们研究的目的是描述1981年至2011年期间法国某中心接触致敏的患病率，以确定某些变应原是否可从当前的BSE中删除。
患者、材料与方法：在皮肤科-变态反应科进行了一项回顾性研究，以分析1981年至2001年每10年进行一次以及2007年至2011年每年进行的所有EBS检测结果。还研究了2010年引入的一些新增变应原。使用 Cochr an-Armitage检验分析变应原阳性率的变化。
在所研究的8年期间纳入的4551例患者中,阳性率为42.91%。普通人群中最常见的变应原是硫酸镍（17.25%），其患病率持续上升，秘鲁香脂（10.68%）、香料混合物I（8.11%）、氯化钴（6.99%）和铬（6.33%）。患病率呈下降趋势的致敏情况最少见的是氯碘羟喹（0.25%）、樱草素（0.54%）和苯佐卡因（0.55%）。
由于变应原暴露情况的改变，接触致敏的发生率可能会发生变化，但尽管有近期的欧洲指令，硫酸镍致敏率仍在上升。阳性结果低于1%的变应原可从EBS中剔除，同时添加苯扎氯铵、甲基异噻唑啉酮和纯薰衣草提取物。
