Sutter R W, Cochi S L, Brink E W, Sirotkin B I
Division of Immunization, Centers for Disease Control, Atlanta, GA 30333.
Am J Epidemiol. 1990 Jan;131(1):132-42. doi: 10.1093/oxfordjournals.aje.a115466.
Reported tetanus cases and tetanus deaths have declined substantially since widespread implementation of tetanus immunization. However, preventable morbidity and mortality continue to occur. During 1979-1984, 74-95 cases of tetanus were reported annually to the Centers for Disease Control (CDC) and 20-31 deaths were reported annually by the National Center for Health Statistics (NCHS). To evaluate further the health impact of tetanus, the authors assessed the completeness of national tetanus mortality data. They reviewed tetanus case report forms received at CDC from the states and NCHS multiple-cause-of-death tapes for 1979-1984. CDC reports recorded 129 deaths and NCHS mortality tapes 197 deaths. Year of death, state, age, and sex were used to match CDC and NCHS deaths, identifying 78 deaths reported to both sources. Using the methodology of Chandra Sekar and Deming, the authors estimated the actual number of tetanus deaths for 1979-1984 to be 326 (95% confidence interval 291-361). Based on this estimate, the completeness of reporting to CDC was 40%, to NCHS 60%, and to the combined systems 76%. To evaluate the reasons for underreporting, the authors contacted 14 states that had reported greater than or equal to 10 cases of tetanus to CDC during 1979-1984 to obtain death certificates for all tetanus deaths and additional information on all tetanus cases. Thirteen states submitted 108 death certificates for review. Coding and other systematic errors did not explain the low reporting efficiency. Failure to list tetanus as a cause of death on the death certificate was the primary reason for nonreporting of tetanus deaths to NCHS. These results suggest that NCHS tetanus mortality data may not be as complete as previously assumed and that tetanus mortality, and probably morbidity, are higher than previous reports have indicated.
自广泛实施破伤风免疫以来,报告的破伤风病例和破伤风死亡人数已大幅下降。然而,可预防的发病和死亡仍在继续发生。1979年至1984年期间,疾病控制中心(CDC)每年报告74至95例破伤风病例,国家卫生统计中心(NCHS)每年报告20至31例死亡。为了进一步评估破伤风对健康的影响,作者评估了国家破伤风死亡率数据的完整性。他们审查了1979年至1984年期间从各州收到的CDC破伤风病例报告表和NCHS多死因磁带。CDC报告记录了129例死亡,NCHS死亡率磁带记录了197例死亡。使用死亡年份、州、年龄和性别来匹配CDC和NCHS的死亡人数,确定向两个来源报告的78例死亡。作者采用钱德拉·塞卡尔和戴明的方法,估计1979年至1984年破伤风死亡的实际人数为326人(95%置信区间291 - 361)。基于这一估计,向CDC报告的完整性为40%,向NCHS报告的完整性为60%,向综合系统报告的完整性为76%。为了评估报告不足的原因,作者联系了1979年至1984年期间向CDC报告了大于或等于10例破伤风病例的14个州,以获取所有破伤风死亡的死亡证明和所有破伤风病例的额外信息。13个州提交了108份死亡证明以供审查。编码和其他系统错误并不能解释报告效率低下的原因。未在死亡证明上列出破伤风作为死亡原因是未向NCHS报告破伤风死亡的主要原因。这些结果表明,NCHS的破伤风死亡率数据可能不像以前假设的那样完整,并且破伤风死亡率以及可能的发病率高于以前的报告所表明的。