Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands.
Pain Med. 2013 Dec;14(12):1893-9. doi: 10.1111/pme.12216. Epub 2013 Aug 19.
The aim of the present study was to investigate whether patients with persistent pain after breast cancer treatment show an enhanced and slowed dominant alpha activity in their electroencephalogram (EEG) recorded during rest in comparison with patients that also had undergone breast cancer treatment but do not have pain.
The spontaneous EEG was recorded during rest and before painful stimulation of the calf and analyzed with spectral analysis (Fast Fourier Transformation). Outcome measures, i.e., alpha indices (center of gravity and overall amplitude), were statistically tested between patients with and without persistent pain.
In comparison with patients without pain, patients with persistent pain after breast cancer treatment show more alpha activity in their spontaneous EEG observed from parietal-occipital brain regions.
Persistent pain after breast cancer treatment affects spontaneous brain activity, which might influence cognitive functioning.
本研究旨在探究接受乳腺癌治疗后仍持续存在疼痛的患者，与同样接受过乳腺癌治疗但无疼痛的患者相比，在静息状态下接受脑电图（EEG）记录时，其大脑中的主导α 活动是否表现出增强和减缓。
在静息状态下和小腿疼痛刺激前记录自发 EEG，并进行频谱分析（快速傅里叶变换）。对有和无持续性疼痛的患者进行统计检验，以评估 α 指数（重心和总幅度）等结果指标。
与无痛患者相比，乳腺癌治疗后持续存在疼痛的患者在顶枕叶脑区观察到的自发 EEG 中表现出更多的α活动。
乳腺癌治疗后的持续性疼痛会影响大脑的自发活动，从而可能影响认知功能。
