National nanotechnology laboratory, al-Farabi Kazakh National University, Almaty, Kazakhstan.
Comput Biol Med. 2013 Oct;43(10):1374-81. doi: 10.1016/j.compbiomed.2013.07.011. Epub 2013 Jul 19.
In this study, we examined 615 host genes encoding 915 in-miRNAs as possible targets for interactions with all in-miRNAs. Host genes whose proteins are involved in esophageal, gastric, small bowel, colorectal, and breast cancer development were studied. Unique in-miRNA binding sites with a significance of p<0.0005 were found in the 5'UTRs, CDSs, and 3'UTRs of the host genes encoding proteins that are key participants in tumourigenesis. These data shed light on the interactions between miRNAs and mRNAs and on the role of candidate proteins in cancer. Therefore, our findings have potential application in the development of diagnostic and treatment methods.
在这项研究中，我们研究了编码 915 个 in-miRNAs 的 615 个宿主基因，作为与所有 in-miRNAs 相互作用的可能靶点。研究了其蛋白质参与食管、胃、小肠、结直肠和乳腺癌发展的宿主基因。在编码参与肿瘤发生的关键蛋白的宿主基因的 5'UTR、CDS 和 3'UTR 中，发现了具有统计学意义（p<0.0005）的独特的 in-miRNA 结合位点。这些数据揭示了 miRNA 和 mRNAs 之间的相互作用以及候选蛋白在癌症中的作用。因此，我们的研究结果在诊断和治疗方法的开发方面具有潜在的应用价值。
