颊黏膜鳞癌的第二原发肿瘤和髓过氧化物酶表达。

Second primary tumors and myeloperoxidase expression in buccal mucosal squamous cell carcinoma.

机构信息

Resident Doctor, Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Director, Pathology Department, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Oct;116(4):464-73. doi: 10.1016/j.oooo.2013.06.018.

DOI:10.1016/j.oooo.2013.06.018

PMID:24035113

Abstract

OBJECTIVE

The present study investigated the relationship between the expression of manganese superoxide dismutase (MnSOD), catalase, glutathione peroxidase (GPx), and myeloperoxidase (MPO) in buccal mucosal squamous cell carcinoma (SCC), and the risk of second primary tumors (SPTs).

STUDY DESIGN

Immunohistochemistry was performed to examine the expression of MnSOD, GPx, catalase, and MPO in tissue microarray slides of 173 male patients with buccal mucosal SCC who had undergone potentially curative resections.

RESULTS

Forty-five (26.01%) patients developed SPTs. The prevalent subsites of SPTs were buccal mucosa (48.89%), tongue (13.33%), and lip (11.11%). High expression level of MPO was correlated with an increased risk of SPTs, even after adjustment for development of clinicopathologic parameters (high vs. low expression, adjusted hazard ratio = 3.89; 95% confidence interval, 1.33-11.41; P = .013).

CONCLUSIONS

SPTs are common in male buccal mucosal SCC patients. Higher MPO expression in buccal mucosal SCC is a risk factor for SPTs.

摘要

目的

本研究旨在探讨口腔颊黏膜鳞状细胞癌（SCC）中锰超氧化物歧化酶（MnSOD）、过氧化氢酶、谷胱甘肽过氧化物酶（GPx）和髓过氧化物酶（MPO）的表达与第二原发肿瘤（SPTs）风险之间的关系。

研究设计

对 173 例经潜在根治性切除的男性口腔颊黏膜 SCC 患者的组织微阵列切片进行免疫组织化学检测，以检测 MnSOD、GPx、过氧化氢酶和 MPO 的表达。

结果

45 例（26.01%）患者发生 SPTs。SPTs 的常见部位为颊黏膜（48.89%）、舌（13.33%）和唇（11.11%）。MPO 的高表达水平与 SPTs 的风险增加相关，即使在校正临床病理参数的发展后也是如此（高表达与低表达相比，调整后的危险比=3.89；95%置信区间，1.33-11.41；P=0.013）。