锰超氧化物歧化酶和谷胱甘肽过氧化物酶作为口腔黏膜鳞状细胞癌患者的预后标志物。

Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas.

机构信息

Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China.

出版信息

Head Neck. 2011 Nov;33(11):1606-15. doi: 10.1002/hed.21653. Epub 2011 Jan 10.

DOI:10.1002/hed.21653

PMID:21990225

Abstract

BACKGROUND

We investigated the relationship of the immunohistochemical expression status of manganese superoxide dismutase (MnSOD), catalase, glutathione peroxidase (GPx), and myeloperoxidase (MPO) in buccal mucosal squamous cell carcinoma (SCC) with clinicopathologic parameters and prognosis.

METHODS

The expression status of MnSOD, GPx, catalase, and MPO was evaluated by immunohistochemistry in a series of 216 surgically resected buccal mucosal SCC specimens, using tissue microarray slides.

RESULTS

MnSOD, GPx, catalase, and MPO were commonly expressed in buccal mucosal SCC. The high expression level of MnSOD was associated with better disease-specific survival (p = .009), especially for patients in moderate or poor cell differentiation (p = .045), pathologic stage I (p = .002) and postoperative radiotherapy (p = .048). The high expression level of GPx was also correlated with better disease-specific survival (p = .042), especially for patients in pathologic stage IV (p = .010) and postoperative radiotherapy (p = .018).

CONCLUSIONS

MnSOD and GPx are significant prognostic factors for favorable survival in patients with buccal mucosal SCC.

摘要

背景

我们研究了锰超氧化物歧化酶（MnSOD）、过氧化氢酶、谷胱甘肽过氧化物酶（GPx）和髓过氧化物酶（MPO）在颊黏膜鳞状细胞癌（SCC）中的免疫组织化学表达状态与临床病理参数和预后的关系。

方法

使用组织微阵列载玻片，通过免疫组织化学方法评估了 216 例手术切除的颊黏膜 SCC 标本中 MnSOD、GPx、过氧化氢酶和 MPO 的表达状态。

结果

MnSOD、GPx、过氧化氢酶和 MPO 在颊黏膜 SCC 中普遍表达。MnSOD 的高表达水平与较好的疾病特异性生存相关（p =.009），尤其是在中等或较差细胞分化（p =.045）、病理分期 I（p =.002）和术后放疗（p =.048）的患者中。GPx 的高表达水平也与较好的疾病特异性生存相关（p =.042），尤其是在病理分期 IV（p =.010）和术后放疗（p =.018）的患者中。