Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden; Department of Medicine and Health Sciences, Linköping University, 581 85 Linköping, Sweden.
Cell Metab. 2013 Oct 1;18(4):478-89. doi: 10.1016/j.cmet.2013.08.008. Epub 2013 Sep 12.
White and brown adipose tissues are hypervascularized and the adipose vasculature displays phenotypic and functional plasticity to coordinate with metabolic demands of adipocytes. Blood vessels not only supply nutrients and oxygen to nourish adipocytes, they also serve as a cellular reservoir to provide adipose precursor and stem cells that control adipose tissue mass and function. Multiple signaling molecules modulate the complex interplay between the vascular system and the adipocytes. Understanding fundamental mechanisms by which angiogenesis and vasculatures modulate adipocyte functions may provide new therapeutic options for treatment of obesity and metabolic disorders by targeting the adipose vasculature.
白色和棕色脂肪组织具有高度血管化的特点，脂肪血管系统表现出表型和功能的可塑性，以协调与脂肪细胞代谢需求的关系。血管不仅为脂肪细胞提供营养和氧气，还作为细胞储存库，为控制脂肪组织质量和功能的脂肪前体和干细胞提供来源。多种信号分子调节血管系统和脂肪细胞之间的复杂相互作用。了解血管生成和血管系统调节脂肪细胞功能的基本机制，可能为通过靶向脂肪血管系统治疗肥胖症和代谢紊乱提供新的治疗选择。
