Xu Luo, Li Zhiling, Guo Feifei
Department of Pathophysiology, Medical College of Qingdao University, Qingdao 266021, Shandong, China.
Eur J Pharmacol. 2013 Oct 15;718(1-3):219-25. doi: 10.1016/j.ejphar.2013.08.030. Epub 2013 Sep 12.
The study was performed to investigate the improved effect of curcumin on gastrointestinal function in streptozotocin-induced diabetic rats. Curcumin was administrated intragastrically at a dose of 100, 200 and 400 mg/kg/day to diabetic rats. After 28 days of treatment, the activity of superoxide dismutase (SOD), catalase (CAT), the content of reduced glutathione (GSH) and malondialdehyde (MDA) in gastric mucosa was assayed. Furthermore, the gastric function was evaluated by hormone secretion and gastric emptying tests. The results indicated that: (i) the diabetic rats exhibited significant decreases in the above mentioned antioxidative enzymes activities and GSH level and exhibited a high level of MDA. After administration of curcumin, the parameters were ameliorated to a large extent; (ii) curcumin treatment dose-dependently augmented the ghrelin levels of stomach and plasma, which were earlier depleted in the diabetic control rats. Conversely, the expression of ghrelin mRNA was decreased after curcumin treatment; and (iii) the gastric emptying in curcumin treated diabetic rats was notably accelerated compared with the diabetic control rats. These findings showed an improved effect of curcumin against streptozotocin-induced gastroparesis possibly by its antioxidant property.
本研究旨在探讨姜黄素对链脲佐菌素诱导的糖尿病大鼠胃肠功能的改善作用。将姜黄素以100、200和400mg/kg/天的剂量灌胃给予糖尿病大鼠。治疗28天后，检测胃黏膜中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）的活性、还原型谷胱甘肽（GSH）和丙二醛（MDA）的含量。此外，通过激素分泌和胃排空试验评估胃功能。结果表明：（i）糖尿病大鼠上述抗氧化酶活性和GSH水平显著降低，MDA水平升高。给予姜黄素后，这些参数在很大程度上得到改善；（ii）姜黄素治疗剂量依赖性地增加了胃和血浆中胃饥饿素水平，而糖尿病对照大鼠中胃饥饿素水平较早降低。相反，姜黄素治疗后胃饥饿素mRNA表达降低；（iii）与糖尿病对照大鼠相比，姜黄素治疗的糖尿病大鼠胃排空明显加快。这些发现表明姜黄素可能通过其抗氧化特性对链脲佐菌素诱导的胃轻瘫有改善作用。
