Abo-Salem Osama M, Harisa Gamaleldin I, Ali Tarek M, El-Sayed El-Sayed M, Abou-Elnour Fatma M
Department of Laboratory Sciences and Clinical Technology, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr-City, Cairo, Egypt.
J Biochem Mol Toxicol. 2014 Jun;28(6):263-70. doi: 10.1002/jbt.21562. Epub 2014 Apr 24.
Heart failure (HF) is one of diabetic complications. This work was designed to investigate the possible modulatory effect of curcumin against streptozotocin-induced diabetes and consequently HF in rats. Rats were divided into control, vehicle-treated, curcumin-treated, diabetic-untreated, diabetic curcumin-treated, and diabetic glibenclamide-treated groups. Animal treatment was started 5 days after induction of diabetes and extended for 6 weeks. Diabetic rats showed significant increase in serum glucose, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, nitric oxide, lactate dehydrogenase, cardiac malondialdehyde, plasma levels of interleukin-6, and tumor necrosis factor-alpha, and also showed marked decrease in serum high-density lipoprotein-cholesterol, cardiac reduced glutathione, and cardiac antioxidant enzymes (catalase, superoxide dismutase, and glutathione-S-transferase). However, curcumin or glibenclamide treatment significantly mitigated such changes. In conclusion, curcumin has a beneficial therapeutic effect in diabetes-induced HF, an effect that might be attributable to its antioxidant and suppressive activity on cytokines.
心力衰竭（HF）是糖尿病并发症之一。本研究旨在探讨姜黄素对链脲佐菌素诱导的糖尿病及随后大鼠HF的可能调节作用。大鼠分为对照组、赋形剂处理组、姜黄素处理组、糖尿病未处理组、糖尿病姜黄素处理组和糖尿病格列本脲处理组。动物治疗在糖尿病诱导后5天开始，持续6周。糖尿病大鼠的血清葡萄糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、一氧化氮、乳酸脱氢酶、心脏丙二醛、白细胞介素-6血浆水平和肿瘤坏死因子-α显著升高，血清高密度脂蛋白胆固醇、心脏还原型谷胱甘肽和心脏抗氧化酶（过氧化氢酶、超氧化物歧化酶和谷胱甘肽-S-转移酶）显著降低。然而，姜黄素或格列本脲治疗显著减轻了这些变化。总之，姜黄素对糖尿病诱导的HF具有有益的治疗作用，这种作用可能归因于其抗氧化和对细胞因子的抑制活性。
