Neurology Department of Affiliated Hospital of Chinese Medicine University of Shandong, Jinan, Shandong 250012, PR China; Neurology Department of the First Affiliated Hospital of Shantou University, Shantou, Guangdong 515041, PR China.
Neurosci Lett. 2013 Oct 25;555:123-8. doi: 10.1016/j.neulet.2013.09.015. Epub 2013 Sep 13.
EGb 761 is main active ingredient of the popular and standardized natural extract Ginkgo biloba, which is known to benefit ischemic stroke. In this study we investigated the potential neuroprotective effect of EGb 761 on the hippocampus in the ischemic/reperfusion rat model. Significant recovery of motor function was seen in EGb 761 treated group compared to vehicle treated group. Infarct volume, as revealed by 1% 2,3,5-triphenyltetrazolium chloride (TTC) staining, was significantly reduced, coupled with conspicuous suppression of neurons apoptosis and significant increments in the cell proliferation and migration in hippocampus. This study reports the therapeutic potential of EGb 761 in stroke animals, which could be related to the attenuation of apoptosis and enhancement of neurogenesis.
银杏叶提取物（EGb 761）是一种广受欢迎的标准化天然提取物银杏叶的主要活性成分，已知对缺血性中风有益。在这项研究中，我们研究了 EGb 761 对缺血/再灌注大鼠模型中海马的潜在神经保护作用。与对照组相比，银杏叶提取物治疗组的运动功能显著恢复。通过 1% 2,3,5-三苯基氯化四氮唑（TTC）染色显示梗塞体积明显减少，同时神经元凋亡明显减少，海马细胞增殖和迁移明显增加。本研究报告了 EGb 761 在中风动物中的治疗潜力，这可能与凋亡的抑制和神经发生的增强有关。
