鼠麴草水提取物对原核生物的诱变和遗传毒性作用。

Mutagenic and genotoxic effects of aqueous extracts of Achyrocline satureoides in prokaryotic organisms.

作者信息

Vargas V M, Motta V E, Leitão A C, Henriques J A

机构信息

Departamento do Meio Ambiente, Porto Alegre, RS, Brazil.

出版信息

Mutat Res. 1990 Jan;240(1):13-8. doi: 10.1016/0165-1218(90)90003-k.

DOI:10.1016/0165-1218(90)90003-k

PMID:2403648

Abstract

Aqueous extracts of Achyrocline satureoides (Marcela and/or Macela) were tested for the presence of genotoxic activity in microorganisms. This species belongs to the family Compositae and is used on a large scale by the population of South Brazil. The extracts showed genotoxic activity in the presence of S9 mix in the Ames test TA100, TA98 and TA102 strains, 'SOS' spot chromotest and Microscreen phage-induction assay. The positive results were related to the presence of quercetin and caffeic acid in the aqueous extracts.

摘要

对牛膝菊（Marcela和/或Macela）的水提取物进行了微生物遗传毒性活性检测。该物种属于菊科，在巴西南部地区被大量使用。在Ames试验的TA100、TA98和TA102菌株、“SOS”斑点染色体试验和微筛噬菌体诱导试验中，提取物在存在S9混合物的情况下显示出遗传毒性活性。阳性结果与水提取物中槲皮素和咖啡酸的存在有关。