Department of Biochemistry, National Institute of Nutrition, Hyderabad, 500007, India,
Rev Endocr Metab Disord. 2013 Sep;14(3):273-86. doi: 10.1007/s11154-013-9268-2.
Lifestyle changes such as dietary habits, sedentary life and consumption of energy-dense foods that have occurred over the years has led to an epidemic of abdominal obesity, which in turn resulted in dramatic increase in the prevalence of metabolic syndrome (MetS). Different expert panels have provided various definitions for MetS to enable a clinical diagnosis and treatment of patients at risk of associated complications. Obesity and obesity mediated MetS has been paralleled by escalation in the incidence of chronic kidney disease (CKD). A better understanding of the pathophysiology of MetS and identification of individuals with MetS early in the life course could be important for initiating interventions such as lifestyle modification and dietary restrictions that form the basis for prevention and treatment of MetS and related co-morbidities including CKD. This review is intended to provide a comprehensive summary of the evolution of definition of MetS and association of MetS with CKD. In particular, mechanism of obesity and diabetes mediated CKD and emerging dietary therapies for MetS associated CKD will be discussed.
生活方式的改变，如饮食习惯、久坐不动的生活方式和能量密集型食物的消费，多年来导致了腹型肥胖的流行，这反过来又导致代谢综合征（MetS）的患病率显著增加。不同的专家小组为 MetS 提供了各种定义，以便对有相关并发症风险的患者进行临床诊断和治疗。肥胖和肥胖介导的 MetS 伴随着慢性肾脏病（CKD）发病率的上升。更好地了解 MetS 的病理生理学，并在生命早期识别出患有 MetS 的个体，对于启动干预措施（如生活方式改变和饮食限制）可能非常重要，这些干预措施是预防和治疗 MetS 及相关合并症（包括 CKD）的基础。这篇综述旨在全面总结 MetS 的定义演变及其与 CKD 的关联。特别是，将讨论肥胖和糖尿病介导的 CKD 的机制以及新兴的用于治疗 MetS 相关 CKD 的饮食疗法。
