Knighton D R, Ciresi K, Fiegel V D, Schumerth S, Butler E, Cerra F
Department of Surgery, University of Minnesota, Minneapolis.
Surg Gynecol Obstet. 1990 Jan;170(1):56-60.
Chronic, nonhealing, cutaneous ulcers are a serious clinical problem. The results of previous studies using platelet-derived wound healing formula (PDWHF), derived from autologous platelets, provided evidence that PDWHF actively stimulates repair of the wound. To test whether or not PDWHF accelerates repair, a prospectively randomized, blinded trial was conducted using a placebo control. A total of 32 patients with chronic, nonhealing, cutaneous wounds of the lower extremity were randomized and treated for eight weeks with PDWHF or placebo. Epithelialization of the wound was the end point of study. In the group who received treatment, 81 per cent of patients had epithelialization in eight weeks compared with 15 per cent in the control group (p less than 0.0001). After crossover to treatment with PDWHF, all of the patients in the control group had epithelialization in an average of 7.1 weeks. Regression analysis of the rates of epithelialization also showed significant differences during the initial eight week trial and showed no difference after crossover of the control group to therapy with PDWHF. Results from this study demonstrate a highly statistically significant effect of topically applied platelet-derived growth factors on the repair of chronic, nonhealing, cutaneous ulcers.
慢性、不愈合的皮肤溃疡是一个严重的临床问题。以往使用源自自体血小板的血小板源性伤口愈合配方（PDWHF）的研究结果表明，PDWHF能积极刺激伤口修复。为了测试PDWHF是否能加速修复，采用安慰剂对照进行了一项前瞻性随机双盲试验。共有32例下肢慢性、不愈合皮肤伤口患者被随机分组，用PDWHF或安慰剂治疗8周。伤口上皮化是研究的终点。在接受治疗的组中，81%的患者在8周内实现了上皮化，而对照组为15%（p<0.0001）。在交叉接受PDWHF治疗后，对照组所有患者平均在7.1周内实现了上皮化。上皮化率的回归分析在最初的8周试验期间也显示出显著差异，而在对照组交叉接受PDWHF治疗后则无差异。这项研究的结果表明，局部应用血小板源性生长因子对慢性、不愈合皮肤溃疡的修复具有高度统计学意义的效果。
