与使用快克可卡因相关的急性胃十二指肠穿孔
Acute gastroduodenal perforations associated with use of crack.
作者信息
Lee H S, LaMaute H R, Pizzi W F, Picard D L, Luks F I
机构信息
Department of Surgery, Catholic Medical Center of Brooklyn, St. Mary's Hospital Division, Jamaica, New York.
出版信息
Ann Surg. 1990 Jan;211(1):15-7. doi: 10.1097/00000658-199001000-00003.
Crack, the free-base form of cocaine, was introduced as an illicit street drug in 1986. Since then, we have noted a significant increase in acute gastroduodenal perforations. Between 1982 and 1986, we treated 11 patients with such perforations. This represents a constant occurrence rate of 6% of hospital admissions for peptic ulcer disease. Since 1986 we have treated 16 patients with gastroduodenal perforation, which yields an occurrence rate of 16%. Nine of the 16 patients had a close temporal relationship between the use of crack and the onset of their perforation. This group was younger and disproportionately comprised of male patients. These findings led us to believe that there may be a pathogenic relationship between the use of crack and acute gastroduodenal perforation, and the clinician should be aware of the various potential complications of this new drug. This relationship also raises questions about the exact pathophysiology of peptic ulcer disease.
快克，即可卡因的游离碱形式，于1986年作为一种非法街头毒品出现。从那时起，我们注意到急性胃十二指肠穿孔的发生率显著增加。1982年至1986年期间，我们治疗了11例此类穿孔患者。这占消化性溃疡疾病住院患者的发生率为6%且保持稳定。自1986年以来，我们治疗了16例胃十二指肠穿孔患者，发生率为16%。16例患者中有9例在使用快克与穿孔发作之间存在密切的时间关系。这组患者较年轻，男性患者比例过高。这些发现使我们相信，使用快克与急性胃十二指肠穿孔之间可能存在致病关系，临床医生应意识到这种新药的各种潜在并发症。这种关系也引发了关于消化性溃疡疾病确切病理生理学的问题。
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