Weiss R L, Ashwood E R, Kjeldsberg C R
Department of Pathology, University of Utah School of Medicine, Salt Lake City 84132.
Arch Pathol Lab Med. 1990 Jan;114(1):28-33.
The clinical, histologic, and immunologic features of 24 cases of multilobated B-cell lymphoma are presented and compared with those of previously reported cases. Cases were included in this study when more than 50% of the tumor cells had nuclear multilobation. There were 13 males and 11 females with an age range of 13 to 79 years. A slight predominance of node-based presentations was observed. Seventeen patients (71%) presented with advanced (stage III or IV) disease. Complete remissions were achieved in 13 (59%) of 22 patients, and 14 (58%) of the 24 patients were still alive after a follow-up period ranging from 10 to 124 months. The 1-year survival was 65% (SE = 10%). Relapses occurred in 4 (31%) of 13 patients with complete responses. These observations, together with those previously reported, support the conclusion that the multilobated B-cell variant of non-Hodgkin's lymphoma behaves in a fashion similar to that of the intermediate-grade, diffuse, large-cell non-Hodgkin's lymphomas.
本文报告了24例多叶状B细胞淋巴瘤的临床、组织学和免疫学特征，并与先前报道的病例进行了比较。当超过50%的肿瘤细胞出现核多叶状时，这些病例被纳入本研究。患者共24例，男性13例，女性11例，年龄范围为13至79岁。观察到以淋巴结受累为主的表现略多。17例患者（71%）表现为晚期（III期或IV期）疾病。22例患者中有13例（59%）实现了完全缓解，24例患者中有14例（58%）在10至124个月的随访期后仍存活。1年生存率为65%（标准误=10%）。13例完全缓解的患者中有4例（31%）复发。这些观察结果，连同先前报道的结果，支持以下结论：非霍奇金淋巴瘤的多叶状B细胞变异型的行为方式与中度恶性、弥漫性大细胞非霍奇金淋巴瘤相似。
