Knighton D R, Fiegel V D, Halverson T, Schneider S, Brown T, Wells C L
Department of Surgery, University of Minnesota, Minneapolis 55455.
Arch Surg. 1990 Jan;125(1):97-100. doi: 10.1001/archsurg.1990.01410130103015.
Previous experimentation with the guinea pig skin injection model showed that altering the fraction of inspired oxygen had a significant effect on infectious necrosis. Using the same model, we performed quantitative bacterial cultures to determine the number of viable injected bacteria 24 and 48 hours after injection. Animals were randomized to receive 12%, 21%, and 45% inspired oxygen. A significant decrease in bacterial number was seen at 45% inspired oxygen between 24 and 48 hours, and a significant decrease occurred at 48 hours between 12% and 45% inspired oxygen. These results demonstrated a prominent role for oxygen in bacterial clearance and host defense.
先前对豚鼠皮肤注射模型的实验表明，改变吸入氧分数对感染性坏死有显著影响。使用相同的模型，我们进行了定量细菌培养，以确定注射后24小时和48小时存活的注射细菌数量。动物被随机分配接受12%、21%和45%的吸入氧。在吸入45%氧气的情况下，24至48小时细菌数量显著减少，在48小时时，吸入12%至45%氧气之间细菌数量显著减少。这些结果证明了氧在细菌清除和宿主防御中起重要作用。
