Knighton D R, Halliday B, Hunt T K
Arch Surg. 1984 Feb;119(2):199-204. doi: 10.1001/archsurg.1984.01390140057010.
Granulocytes' in vitro bactericidal capacity for certain bacteria depends on an adequate environmental oxygen supply. Oxygen available to granulocytes in infected tissue is decreased by local conditions and can be altered significantly by small changes in its inspired concentration. We modified Burke's and Miles' bacteria-injection model in animals to test the effect of breathing 12%, 21%, and 45% oxygen on the size of lesions produced by intradermal injections of Escherichia coli. Moderately increased inspired oxygen concentrations (fraction of inspired oxygen [Flo2]) significantly decreased the size and number of necrotic lesions, whereas hypoxia increased both. Increasing Flo2 to 45% after three and 24 hours of hypoxia also significantly decreased lesion size. Suppression of infection by moderate hyperoxia is comparable with that reported by Burke after timely, adequate doses of type-specific antibiotics.
粒细胞对某些细菌的体外杀菌能力取决于充足的环境氧气供应。感染组织中粒细胞可利用的氧气会因局部条件而减少，并且其吸入浓度的微小变化也会使其发生显著改变。我们对动物体内伯克氏和迈尔斯氏细菌注射模型进行了改良，以测试吸入12%、21%和45%氧气对皮内注射大肠杆菌所产生损伤大小的影响。适度提高吸入氧气浓度（吸入氧分数[Flo2]）可显著减小坏死损伤的大小和数量，而低氧则会使其增加。在低氧3小时和24小时后将Flo2提高到45%也可显著减小损伤大小。适度高氧对感染的抑制作用与伯克氏在及时给予足量的型特异性抗生素后所报告的效果相当。
