Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Int Health. 2011 Sep;3(3):165-75. doi: 10.1016/j.inhe.2011.06.002.
In schistosomiasis control, there is a need to geographically target treatment to populations at high risk of morbidity. This paper evaluates alternative sampling strategies for surveys of Schistosoma mansoni to target mass drug administration in Kenya and Ethiopia. Two main designs are considered: lot quality assurance sampling (LQAS) of children from all schools; and a geostatistical design that samples a subset of schools and uses semi-variogram analysis and spatial interpolation to predict prevalence in the remaining unsurveyed schools. Computerized simulations are used to investigate the performance of sampling strategies in correctly classifying schools according to treatment needs and their cost-effectiveness in identifying high prevalence schools. LQAS performs better than geostatistical sampling in correctly classifying schools, but at a cost with a higher cost per high prevalence school correctly classified. It is suggested that the optimal surveying strategy for S. mansoni needs to take into account the goals of the control programme and the financial and drug resources available.
在血吸虫病防治中，需要对高发病率风险人群进行地理靶向治疗。本文评估了替代抽样策略，用于肯尼亚和埃塞俄比亚的曼氏血吸虫大规模药物治疗调查。主要考虑了两种设计：从所有学校抽取儿童的整群质量保证抽样（LQAS）；以及一种地统计设计，抽取一部分学校，并使用半变异分析和空间插值来预测其余未抽样学校的流行率。计算机模拟用于研究抽样策略在根据治疗需求正确分类学校方面的性能及其在识别高流行率学校方面的成本效益。LQAS 在正确分类学校方面优于地统计抽样，但成本更高，每所正确分类的高流行率学校的成本更高。因此，建议曼氏血吸虫的最佳调查策略需要考虑控制计划的目标以及可用的财务和药物资源。
