Department of Occupational Therapy, University of Pittsburgh School of Health and Rehabilitation Sciences, Pittsburgh, Pennsylvania; Department of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; University of Pittsburgh Medical Center Rehabilitation Institute, Pittsburgh, Pennsylvania.
Pediatr Blood Cancer. 2014 Oct;61(10):1743-6. doi: 10.1002/pbc.24781. Epub 2013 Sep 13.
Cancer and its life-saving treatments often result in long-term impairments in neurocognitive functions. These neurocognitive impairments are not only problematic, but they also limit the ability to perform meaningful everyday activities critical to independence in the home, school, and community. The "bottom-up" and "top-down" models inherent in many neurological rehabilitation interventions provide a gross framework for describing interventions designed to address neurocognitive functions. Activity interventions show promise for improving performance of everyday activities, as well as improving underlying neurocognitive functions. However, additional empirical examination is warranted. Future studies examining activity interventions should clearly specify the active ingredient of the intervention, and evaluate the impact of the intervention on neurocognitive as well as activity-based outcomes.
癌症及其挽救生命的治疗方法常常导致神经认知功能的长期损伤。这些神经认知损伤不仅成问题，而且还限制了在家庭、学校和社区中独立进行有意义的日常活动的能力。许多神经康复干预措施中固有的“自下而上”和“自上而下”模型为描述旨在解决神经认知功能的干预措施提供了一个大致框架。活动干预措施显示出改善日常活动表现以及改善潜在神经认知功能的潜力。然而，需要进一步的实证检验。未来研究应明确干预措施的活性成分，并评估干预措施对神经认知和基于活动的结果的影响。
