Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King's College London, , London, UK.
J Neurol Neurosurg Psychiatry. 2014 Feb;85(2):227-9. doi: 10.1136/jnnp-2013-305012. Epub 2013 Sep 13.
To investigate potential abnormalities in subcortical brain structures in conversion disorder (CD) compared with controls using a region of interest (ROI) approach.
Fourteen patients with motor CD were compared with 31 healthy controls using high-resolution MRI scans with an ROI approach focusing on the basal ganglia, thalamus and amygdala. Brain volumes were measured using Freesurfer, a validated segmentation algorithm.
Significantly smaller left thalamic volumes were found in patients compared with controls when corrected for intracranial volume. These reductions did not vary with handedness, laterality, duration or severity of symptoms.
These differences may reflect a primary disease process in this area or be secondary effects of the disorder, for example, resulting from limb disuse. Larger, longitudinal structural imaging studies will be required to confirm the findings and explore whether they are primary or secondary to CD.
采用基于感兴趣区（ROI）的方法，研究转换障碍（CD）与对照组相比，皮质下脑结构的潜在异常。
使用高分辨率 MRI 扫描和基于 ROI 的方法，对 14 例运动性 CD 患者和 31 名健康对照者进行比较，重点关注基底节、丘脑和杏仁核。使用 Freesurfer （一种经过验证的分割算法）测量脑体积。
校正颅内体积后，与对照组相比，患者的左侧丘脑体积明显较小。这些减少与利手性、偏侧性、症状持续时间或严重程度无关。
这些差异可能反映了该区域的原发性疾病过程，或者是该疾病的继发性影响，例如，由于肢体失用导致的影响。需要更大规模的纵向结构成像研究来证实这些发现，并探讨它们是原发性的还是继发于 CD。
