Reinders Antje A T S, Dimitrova Lora I, Schlumpf Yolanda R, Vissia Eline M, Nijenhuis Ellert R S, Jäncke Lutz, Chalavi Sima, Veltman Dick J
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; and Department of Psychiatry, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, The Netherlands.
BJPsych Open. 2022 Mar 15;8(2):e70. doi: 10.1192/bjo.2022.36.
Studies investigating the structure of the amygdala in relation to dissociation in psychiatric disorders are limited and have reported normal or preserved, increased or decreased global volumes. Thus, a more detailed investigation of the amygdala is warranted. Amygdala global and subregional volumes were compared between individuals with dissociative identity disorder (DID: n = 32) and healthy controls (n = 42). Analyses of covariance did not show volumetric differences between the DID and control groups. Although several unknowns make it challenging to interpret our findings, we propose that the finding of normal amygdala volume is a genuine finding because other studies using this data-set have presented robust morphological aberrations in relation to the diagnosis of DID.
研究精神疾病中与解离相关的杏仁核结构的研究有限，且报告的总体积有正常或保留、增加或减少的情况。因此，有必要对杏仁核进行更详细的研究。比较了分离性身份障碍患者（DID：n = 32）和健康对照者（n = 42）的杏仁核总体积和亚区域体积。协方差分析未显示DID组和对照组之间存在体积差异。尽管有几个未知因素使得解释我们的发现具有挑战性，但我们认为杏仁核体积正常这一发现是真实的，因为使用该数据集的其他研究已经呈现出与DID诊断相关的明显形态学异常。
