IgG4相关疾病中RP105阴性B细胞增多。
Increased RP105-Negative B Cells in IgG4-Related Disease.
作者信息
Koarada S, Tashiro S, Nagao N, Suematsu R, Ohta A, Tada Y
机构信息
Division of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.
出版信息
Open Rheumatol J. 2013 Aug 23;7:55-7. doi: 10.2174/1874312901307010055. eCollection 2013.
Four patients with IgG4-related disease (IgG4-RD) showed increased percentages of RP105-negative B cells in the peripheral blood. Case 1: A 66-year-old man having retroperitoneal fibrosis had 18.8% of RP105-negative B cells. Oral prednisolone improved the affected lesions and the percentage of RP105-negative B cells decreased (3.2%) after the treatment. Case 2: A 53-year-old man with retroperitoneal fibrosis had 27.9% of RP105-negative B cells. Case 3: A 38-year-old man with follicular hyperplasia showed increased percentage of RP105-negative B cells (8.3%). Case 4: A 60-year-old man with interstitial nephritis had 27.5% of RP105-negative B cells. The treatment decreased the numbers of RP105-negative B cells. Increased numbers of RP105-negatvie B cells is possibly associated with disease activity of IgG4-RD. Analysis of expression of RP105 on B cells may be helpful in evaluation of disease activity of IgG4-RD.
4例IgG4相关性疾病（IgG4-RD）患者外周血中RP105阴性B细胞百分比升高。病例1：一名66岁患有腹膜后纤维化的男性，其RP105阴性B细胞占18.8%。口服泼尼松龙使受累病变改善，治疗后RP105阴性B细胞百分比下降（3.2%）。病例2：一名53岁患有腹膜后纤维化的男性，其RP105阴性B细胞占27.9%。病例3：一名38岁患有滤泡增生的男性，其RP105阴性B细胞百分比升高（8.3%）。病例4：一名60岁患有间质性肾炎的男性，其RP105阴性B细胞占27.5%。治疗使RP105阴性B细胞数量减少。RP105阴性B细胞数量增加可能与IgG4-RD的疾病活动相关。分析B细胞上RP105的表达可能有助于评估IgG4-RD的疾病活动。
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