Schweizer E, Rickels K, Amsterdam J D, Fox I, Puzzuoli G, Weise C
Private Practice Research Group, University of Pennsylvania, Philadelphia.
J Clin Psychiatry. 1990 Jan;51(1):8-11.
One hundred and eight patients with major depression were treated with fluoxetine 20 mg/day for 3 weeks. Patients who failed to respond to this open-label treatment were randomly assigned either to receive fluoxetine 60 mg/day for 5 weeks or to continue treatment with fluoxetine 20 mg/day for an additional 5 weeks. Both treatment groups demonstrated a statistically significant reduction in depressive symptoms, indicating that continued treatment with low-dose fluoxetine may be as effective as an increase in dose in achieving a favorable clinical outcome.
108名重度抑郁症患者接受了为期3周的每天20毫克氟西汀治疗。对这种开放标签治疗无反应的患者被随机分配，要么接受为期5周的每天60毫克氟西汀治疗，要么继续接受为期5周的每天20毫克氟西汀治疗。两个治疗组的抑郁症状均有统计学意义的减轻，这表明低剂量氟西汀持续治疗在实现良好临床结果方面可能与增加剂量一样有效。
