Morrissey P J, Charrier K
Immunex Corporation, Seattle, WA 98101.
J Immunol. 1990 Jan 15;144(2):557-61.
Ity resistant A/J mice were challenged with a lethal dose (2 x 10(3) organisms) of Salmonella typhimurium. Infected mice treated with 1 microgram of GM-CSF twice daily showed increased median survival time and had a higher survival fraction than untreated controls. GM-CSF was most effective when given for a brief period (1 to 2 days) after infection. Pretreatment of the mice or delayed treatment with GM-CSF had no effect on the survival of the mice. Studies on the effect of GM-CSF on the bacterial load showed that mice treated with GM-CSF had fewer S. typhimurium in the spleen and peritoneal cavity on day 4 but not on day 2 after infection. GM-CSF treatment of ity-susceptible C57BL/6 mice infected with 10 organisms had no therapeutic effect.
用致死剂量（2×10³个菌）的鼠伤寒沙门氏菌攻击对感染易感性有抗性的A/J小鼠。每天两次用1微克粒细胞-巨噬细胞集落刺激因子（GM-CSF）治疗的感染小鼠，其平均存活时间延长，存活比例高于未治疗的对照组。GM-CSF在感染后短时间（1至2天）给药时效果最佳。小鼠的预处理或GM-CSF的延迟治疗对小鼠的存活没有影响。关于GM-CSF对细菌载量影响的研究表明，用GM-CSF治疗的小鼠在感染后第4天脾脏和腹腔中的鼠伤寒沙门氏菌数量较少，但在感染后第2天没有减少。用GM-CSF治疗感染10个菌的对感染易感的C57BL/6小鼠没有治疗效果。
