Corcoran L M, Metcalf D, Edwards S J, Handman E
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
J Parasitol. 1988 Oct;74(5):763-7.
The hemopoietic growth and differentiation regulators, granulocyte-macrophage colony-stimulating factor (GM-CSF) and the multipotential stimulating factor (multi-CSF) have been shown to have major effects on the effector function of mature macrophages. In this study we have examined the effect of recombinant GM-CSF and multi-CSF expressed transiently from recombinant vaccinia virus, or constitutively in GM-CSF transgenic mice on the development of cutaneous leishmaniasis, caused by Leishmania major in genetically susceptible or resistant mice. We observed no effect on the development of lesions when GM-CSF or multi-CSF were administered before infection, nor on the healing of lesions when they were administered after appearance of lesions. Although only some of the GM-CSF transgenic mice or their normal littermates developed lesions after infection with L. major, there was no difference between the groups in the rate of lesion development or in the size of lesions.
造血生长和分化调节因子，即粒细胞巨噬细胞集落刺激因子（GM-CSF）和多能刺激因子（multi-CSF），已被证明对成熟巨噬细胞的效应功能有重大影响。在本研究中，我们检测了重组痘苗病毒瞬时表达的重组GM-CSF和multi-CSF，或GM-CSF转基因小鼠中组成性表达的这两种因子，对由硕大利什曼原虫引起的皮肤利什曼病在基因易感或抗性小鼠中的发展情况的影响。我们观察到，在感染前给予GM-CSF或multi-CSF对病变发展没有影响，在病变出现后给予也对病变愈合没有影响。虽然只有部分GM-CSF转基因小鼠或其正常同窝小鼠在感染硕大利什曼原虫后出现病变，但两组在病变发展速度或病变大小方面没有差异。
