Edwards M S, Hall M A, Rench M A, Baker C J
Myers Black Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
J Infect Dis. 1990 Jan;161(1):65-70. doi: 10.1093/infdis/161.1.65.
Serum samples from 10 infants surviving type III, group B streptococcal (GBS) meningitis were collected acutely and longitudinally for 6 months to determine patterns of antibody response to the capsular polysaccharide and their in vitro functional correlates. Five infants who failed to develop specific antibody at a mean of 3.8 weeks after diagnosis had an increase of greater than or equal to 1.0 microgram/ml after another 4-8 weeks. This IgM-predominant type-specific antibody declined to baseline 2-4 months later. Opsonophagocytosis of type III GBS increased from 0 to 88% in parallel with peak antibody response. Three infants developed increased antibody and opsonophagocytosis at 15-31 weeks after diagnosis, while two had no detectable response. Despite increasing complement levels, opsonophagocytosis of type III GBS was poor with low specific antibody levels These results suggest that survivors of GBS meningitis transiently develop specific antibody and associated efficient opsonophagocytosis, but functional competence does not persist despite maturation to adult levels of complement proteins.
收集了10例存活的Ⅲ型B族链球菌（GBS）脑膜炎婴儿的血清样本，分别在急性期和长达6个月的时间内纵向采集，以确定对荚膜多糖的抗体反应模式及其体外功能相关性。5例在诊断后平均3.8周未能产生特异性抗体的婴儿，在另外4 - 8周后抗体增加至≥1.0微克/毫升。这种以IgM为主的型特异性抗体在2 - 4个月后降至基线水平。Ⅲ型GBS的调理吞噬作用从0增加到88%，与抗体反应峰值平行。3例婴儿在诊断后15 - 31周抗体和调理吞噬作用增加，而2例无可检测到的反应。尽管补体水平升高，但特异性抗体水平低时，Ⅲ型GBS的调理吞噬作用较差。这些结果表明，GBS脑膜炎幸存者短暂产生特异性抗体并伴有有效的调理吞噬作用，但尽管补体蛋白成熟至成人水平，功能能力并不持久。
