Department of Immunology, School of Medicine, University of Córdoba , Córdoba , Spain.
Int Rev Immunol. 2013 Oct-Dec;32(5-6):534-43. doi: 10.3109/08830185.2013.834898. Epub 2013 Sep 16.
Celiac disease (CD) is a very common chronic condition in human beings, affecting approximately one in 100 individuals. It is an autoimmune disease with a defined environmental trigger, the gluten contained in dietary cereals, occurring in genetically susceptible individuals. The disease has a very strong HLA association. More than 90% of CD patients have HLA-DQ2, and almost all of the remaining celiac population possesses HLA-DQ8 molecules. Th17 cells seem to participate in the disease pathogenesis producing and secreting either proinflammatory or anti-inflammatory cytokines.
乳糜泻（CD）是一种非常常见的人类慢性疾病，大约每 100 个人中就有 1 人患病。它是一种自身免疫性疾病，具有明确的环境触发因素，即饮食谷物中的麸质，发生在遗传易感个体中。这种疾病与 HLA 有很强的关联。超过 90%的 CD 患者携带 HLA-DQ2，而几乎所有剩余的乳糜泻人群都拥有 HLA-DQ8 分子。Th17 细胞似乎参与了疾病的发病机制，产生和分泌促炎或抗炎细胞因子。
