Dayan Saim, Tekin Alicem, Tekin Recep, Dal Tuba, Hoşoğlu Salih, Yazgan Umit Can, Bekçibaşı Muhammet, Gül Kadri
Dicle University, Faculty of Medicine, Diyarbakir, Turkey.
J Infect Dev Ctries. 2013 Sep 16;7(9):665-9. doi: 10.3855/jidc.2835.
This study investigated the seroprevalence of hepatitis B virus surface antigen (HBsAg), antibody against hepatitis C virus (anti-HCV), antibody against human immunodeficiency virus type 1/2 (anti-HIV 1/2), and antibody against Treponema pallidum (anti-Treponemal or syphilis antibody) in healthy volunteer blood donors, and assessed their distribution according to the years and genders.
HBsAg, anti-HCV, anti-HIV ½, and syphilis screening results of a total of 266,035 healthy volunteer blood donors who had been admitted for blood donation to the Regional Blood Center of Dicle University Hospital between January 2000 and December 2010 were evaluated, retrospectively. HBsAg, anti-HCV, and anti-HIV 1/2 screening were performed using a fully automated device with the microparticle enzyme immunoassay method (MEIA). Syphilis screening was performed by Rapid Plasma Reagin (RPR) carbon test between January 2000 and December 2009, and by using a fully automated device with the MEIA method between January 2010 and December 2010.
Of 266,035 healthy volunteer blood donors, 259,384 (97.5%) were male and 6,651 (2.5%) were female. Statistically, there was not any significant difference between male and female genders for HBsAg, anti-HCV and syphilis seropositivities (P = 0.729, P = 0.748, and P = 0.861, respectively). HBsAg was found to be positive in 8,422 (3.17%), anti-HCV in 1,703 (0.64%), anti-HIV 1/2 in one (0.0004%) of 266,035 healthy volunteer blood donors, and syphilis antibody with RPR in 166 (0.07%) of 246,341 healthy volunteer blood donors.
Blood donor forms should be carefully tailored to improve the identification of possible risks of transfusion-transmitted infections.
本研究调查了健康无偿献血者中乙肝病毒表面抗原（HBsAg）、丙型肝炎病毒抗体（抗-HCV）、人类免疫缺陷病毒1/2型抗体（抗-HIV 1/2）和梅毒螺旋体抗体（抗梅毒抗体）的血清流行率，并根据年份和性别评估了它们的分布情况。
回顾性评估了2000年1月至2010年12月期间在迪克莱大学医院地区血库接受献血的266,035名健康无偿献血者的HBsAg、抗-HCV、抗-HIV 1/2和梅毒筛查结果。HBsAg、抗-HCV和抗-HIV 1/2筛查采用全自动设备，通过微粒酶免疫分析法（MEIA）进行。2000年1月至2009年12月梅毒筛查采用快速血浆反应素（RPR）炭凝集试验，2010年1月至2010年12月采用全自动设备通过MEIA法进行。
在266,035名健康无偿献血者中，259,384名（97.5%）为男性，6,651名（2.5%）为女性。统计学上，男性和女性在HBsAg、抗-HCV和梅毒血清阳性率方面没有显著差异（分别为P = 0.729、P = 0.748和P = 0.861）。在266,035名健康无偿献血者中，发现8,422名（3.17%）HBsAg呈阳性，1,703名（0.64%）抗-HCV呈阳性，1名（0.0004%）抗-HIV 1/2呈阳性；在246,341名健康无偿献血者中，166名（0.07%）梅毒抗体RPR呈阳性。
应仔细调整献血者表格，以更好地识别输血传播感染的潜在风险。
