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一种具有 TEMPO 自由基单元的高细胞毒性修饰的保罗酮配体及其铜(II)配合物作为潜在的 hR2 RNR 抑制剂。

A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors.

机构信息

Institute of Inorganic Chemistry of the University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria.

出版信息

Chem Commun (Camb). 2013 Nov 4;49(85):10007-9. doi: 10.1039/c3cc45743e.

DOI:10.1039/c3cc45743e
PMID:24042148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4047831/
Abstract

A new paullone-TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.

摘要

一种新的保罗酮-TEMPO 缀合物及其铜（II）配合物抑制 RNR 活性，并在人癌细胞系中显示出高的抗增殖活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/f985cd8cc03e/c3cc45743e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/0e00166a9295/c3cc45743e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/56e0997d5a67/c3cc45743e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/fa51fba60e01/c3cc45743e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/dd7f9d33121e/c3cc45743e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/f985cd8cc03e/c3cc45743e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/0e00166a9295/c3cc45743e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/56e0997d5a67/c3cc45743e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/fa51fba60e01/c3cc45743e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/dd7f9d33121e/c3cc45743e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfa/4047831/f985cd8cc03e/c3cc45743e-f5.jpg

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