Therrien Bruno
Institut de chimie, Université de Neuchâtel, Switzerland.
Top Curr Chem. 2012;319:35-55. doi: 10.1007/128_2011_272.
Until recently, organometallic derivatives were generally viewed as moisture- and air-sensitive compounds, and consequently very challenging to synthesise and very demanding in terms of laboratory requirements (Schlenk techniques, dried solvent, glove box). However, an increasing number of stable, water-soluble organometallic compounds are now available, and organometallic chemistry in aqueous phase is a flourishing area of research. As such, coordination-driven self-assemblies using organometallic building blocks are compatible with water, thus opening new perspectives in bio-organometallic chemistry.This chapter gives a short history of coordination-driven self-assembly, with a special attention to organometallic metalla-cycles, especially those composed of half-sandwich complexes. These metalla-assemblies have been used as sensors, as anticancer agents, as well as drug carriers.
直到最近，有机金属衍生物通常还被视为对水分和空气敏感的化合物，因此合成极具挑战性，对实验室条件（施伦克技术、干燥溶剂、手套箱）要求极高。然而，现在已有越来越多稳定的水溶性有机金属化合物，水相中的有机金属化学是一个蓬勃发展的研究领域。因此，使用有机金属构建单元的配位驱动自组装与水兼容，从而为生物有机金属化学开辟了新的前景。本章简要介绍了配位驱动自组装的历史，特别关注有机金属金属环，尤其是那些由半夹心配合物组成的金属环。这些金属组装体已被用作传感器、抗癌剂以及药物载体。
