Headache Research and Treatment Program, Department of Neurology, David Geffen School of Medicine at UCLA, Neuroscience Research Building 1, Room 575, 635 Charles Young Drive South, Los Angeles, CA 90095-7335, USA.
Nat Rev Neurol. 2013 Nov;9(11):637-44. doi: 10.1038/nrneurol.2013.192. Epub 2013 Sep 17.
Cortical spreading depression (CSD), a slowly propagated wave of depolarization followed by suppression of brain activity, is a remarkably complex event that involves dramatic changes in neural and vascular function. Since its original description in the 1940s, CSD has been hypothesized to be the underlying mechanism of the migraine aura. Substantial evidence from animal models provides indirect support for this hypothesis, and studies showing that CSD is common in humans with brain injury clearly demonstrate that the phenomenon can occur in the human brain. Considerable uncertainty about the role of CSD in migraine remains, however, and key questions about how this event is initiated, how it spreads, and how it might cause migraine symptoms remain unanswered. This Review summarizes current concepts of CSD and its potential roles in migraine, and addresses ongoing studies aimed at a clearer understanding of this fundamental brain phenomenon.
皮层扩散性抑制（CSD）是一种缓慢传播的去极化波，随后是脑活动抑制，是一种非常复杂的事件，涉及到神经和血管功能的显著变化。自 20 世纪 40 年代首次描述以来，CSD 一直被假设为偏头痛先兆的潜在机制。动物模型的大量证据为此假说提供了间接支持，而表明 CSD 在脑损伤患者中很常见的研究清楚地表明，这种现象可以在人类大脑中发生。然而，关于 CSD 在偏头痛中的作用仍存在相当大的不确定性，关于该事件如何引发、如何传播以及如何引起偏头痛症状的关键问题仍未得到解答。这篇综述总结了 CSD 的当前概念及其在偏头痛中的潜在作用，并讨论了旨在更清楚地了解这一基本脑现象的正在进行的研究。
