Mukamal Kenneth J, Wilk Jemma B, Biggs Mary L, Jensen Majken K, Ix Joachim H, Kizer Jorge R, Tracy Russell P, Zieman Susan J, Mozaffarian Dariush, Psaty Bruce M, Siscovick David S, Djoussé Luc
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Lipids. 2013 Nov;48(11):1169-75. doi: 10.1007/s11745-013-3838-7. Epub 2013 Sep 17.
We examined common variants in the fatty acid binding protein 4 gene (FABP4) and plasma levels of FABP4 in adults aged 65 and older from the Cardiovascular Health Study. We genotyped rs16909187, rs1054135, rs16909192, rs10808846, rs7018409, rs2290201, and rs6992708 and measured circulating FABP4 levels among 3190 European Americans and 660 African Americans. Among European Americans, the minor alleles of six single nucleotide polymorphisms (SNP) were associated with lower FABP4 levels (all p ≤ 0.01). Among African Americans, the SNP with the lowest minor allele frequency was associated with lower FABP4 levels (p = 0.015). The C-A haplotype of rs16909192 and rs2290201 was associated with lower FABP4 levels in both European Americans (frequency = 16 %; p = 0.001) and African Americans (frequency = 8 %; p = 0.04). The haplotype combined a SNP in the first intron with one in the 3'untranslated region. However, the alleles associated with lower FABP4 levels were associated with higher fasting glucose in meta-analyses from the MAGIC consortium. These results demonstrate associations of common SNP and haplotypes in the FABP4 gene with lower plasma FABP4 but higher fasting glucose levels.
我们对心血管健康研究中65岁及以上成年人的脂肪酸结合蛋白4基因（FABP4）常见变异及FABP4血浆水平进行了检测。我们对rs16909187、rs1054135、rs16909192、rs10808846、rs7018409、rs2290201和rs6992708进行了基因分型，并测量了3190名欧裔美国人和660名非裔美国人的循环FABP4水平。在欧裔美国人中，6个单核苷酸多态性（SNP）的次要等位基因与较低的FABP4水平相关（所有p≤0.01）。在非裔美国人中，次要等位基因频率最低的SNP与较低的FABP4水平相关（p = 0.015）。rs16909192和rs2290201的C - A单倍型在欧裔美国人（频率 = 16%；p = 0.001）和非裔美国人（频率 = 8%；p = 0.04）中均与较低的FABP4水平相关。该单倍型将第一个内含子中的一个SNP与3'非翻译区中的一个SNP组合在一起。然而，在MAGIC联盟的荟萃分析中，与较低FABP4水平相关的等位基因与较高的空腹血糖相关。这些结果表明，FABP4基因中的常见SNP和单倍型与较低的血浆FABP4水平但较高的空腹血糖水平相关。
