Kapran Ziya, Ozkaya Abdullah, Uyar O Murat
Ophthalmic Surg Lasers Imaging Retina. 2013 Sep-Oct;44(5):471-6. doi: 10.3928/23258160-20130909-09.
To investigate the outcomes of vitrectomy, subretinal tissue plasminogen (tPA) injection, gas tamponade, and upright positioning in patients with hemorrhagic neovascular age-related macular degeneration (AMD).
Retrospective, noncomparative case series. Records of patients who were diagnosed with submacular hemorrhage secondary to neovascular AMD and underwent treatment with the combined method between 2004 and 2010 were reviewed. The main outcome measure was the difference between preoperative and post-operative best corrected visual acuity (BCVA).
In 10 eyes of 10 patients, mean preoperative and postoperative BCVA values were 1.75 and 1.23 logMAR, respectively (P = .011), after a mean follow-up time of 38.7 ± 26.5 months (range: 10 to 71 months). Eight of 10 patients (80%) gained at least three lines.
In patients with hemorrhagic neovascular AMD, treatment with vitrectomy, subretinal tPA injection, gas tamponade, and upright positioning was associated with better visual outcomes than those reported for patients with untreated disease.
探讨玻璃体切除术、视网膜下组织型纤溶酶原（tPA）注射、气体填塞及体位直立对出血性新生血管性年龄相关性黄斑变性（AMD）患者的治疗效果。
回顾性、非对照病例系列研究。回顾2004年至2010年间被诊断为新生血管性AMD继发黄斑下出血并接受联合治疗的患者记录。主要观察指标为术前与术后最佳矫正视力（BCVA）的差异。
10例患者的10只眼中，平均随访时间为38.7±26.5个月（范围：10至71个月），术前与术后BCVA平均值分别为1.75和1.23 logMAR（P = 0.011）。10例患者中有8例（80%）视力至少提高了3行。
对于出血性新生血管性AMD患者，玻璃体切除术、视网膜下tPA注射、气体填塞及体位直立治疗比未治疗患者的视力预后更好。
