Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México.
HIPAM, Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM)/Hospital General de México, México.
Mol Cell Endocrinol. 2014 Jan 25;382(1):538-549. doi: 10.1016/j.mce.2013.09.008. Epub 2013 Sep 14.
The recent growth of interest in developmental programming of physiological systems has generally focused on the cardiovascular system (especially hypertension) and predisposition to metabolic dysfunction (mainly obesity and diabetes). However, it is now clear that the full range of altered offspring phenotypes includes impaired reproductive function. In rats, sheep and nonhuman primates, reproductive capacity is altered by challenges experienced during critical periods of development. This review will examine available experimental evidence across commonly studied experimental species for developmental programming of female and male reproductive function throughout an individual's life-course. It is necessary to consider events that occur during fetal development, early neonatal life and prior to and during puberty, during active reproductive life and aging as reproductive performance declines.
近年来，人们对生理系统发育编程的兴趣日益浓厚，研究主要集中在心血管系统（特别是高血压）和代谢功能障碍易感性（主要是肥胖和糖尿病）上。然而，现在很明显，受干扰的后代表型的范围很广，包括生殖功能受损。在大鼠、绵羊和非人灵长类动物中，生殖能力会因发育关键期所经历的挑战而发生改变。这篇综述将检查在常见的实验物种中，有哪些实验证据可以证明个体生命全程的雌性和雄性生殖功能的发育编程。有必要考虑胎儿发育、新生儿早期以及青春期前和青春期、生殖活跃期和生殖能力下降的衰老期等阶段发生的事件。
