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代际高血糖症可损害线粒体功能和卵泡发育，并导致大鼠卵巢发生氧化应激，而与高脂肪饮食的摄入无关。

Intergenerational Hyperglycemia Impairs Mitochondrial Function and Follicular Development and Causes Oxidative Stress in Rat Ovaries Independent of the Consumption of a High-Fat Diet.

机构信息

Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Postgraduate Course on Tocogynecology, Botucatu Medical School, São Paulo State University (Unesp), Botucatu 18618-687, SP, Brazil.

Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.

出版信息

Nutrients. 2023 Oct 17;15(20):4407. doi: 10.3390/nu15204407.

DOI:10.3390/nu15204407
PMID:37892483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10609718/
Abstract

We analyzed the influence of maternal hyperglycemia and the post-weaning consumption of a high-fat diet on the mitochondrial function and ovarian development of the adult pups of diabetic rats. Female rats received citrate buffer (Control-C) or Streptozotocin (for diabetes induction-D) on postnatal day 5. These adult rats were mated to obtain female pups (O) from control dams (OC) or from diabetic dams (OD), and they received a standard diet (SD) or high-fat diet (HFD) from weaning to adulthood and were distributed into OC/SD, OC/HFD, OD/SD, and OD/HFD. In adulthood, the OGTT and AUC were performed. These rats were anesthetized and euthanized for sample collection. A high percentage of diabetic rats were found to be in the OD/HFD group (OD/HFD 40% vs. OC/SD 0% < 0.05). Progesterone concentrations were lower in the experimental groups (OC/HFD 0.40 ± 0.04; OD/SD 0.30 ± 0.03; OD/HFD 0.24 ± 0.04 vs. OC/SD 0.45 ± 0.03 < 0.0001). There was a lower expression of MFF (OD/SD 0.34 ± 0.33; OD/HFD 0.29 ± 0.2 vs. OC/SD 1.0 ± 0.41 = 0.0015) and MFN2 in the OD/SD and OD/HFD groups (OD/SD 0.41 ± 0.21; OD/HFD 0.77 ± 0.18 vs. OC/SD 1.0 ± 0.45 = 0.0037). The number of follicles was lower in the OD/SD and OD/HFD groups. A lower staining intensity for SOD and Catalase and higher staining intensity for MDA were found in ovarian cells in the OC/HFD, OD/SD, and OD/HFD groups. Fetal programming was responsible for mitochondrial dysfunction, ovarian reserve loss, and oxidative stress; the association of maternal diabetes with an HFD was responsible for the higher occurrence of diabetes in female adult pups.

摘要

我们分析了母体高血糖和断奶后高脂肪饮食对糖尿病大鼠后代成年幼崽的线粒体功能和卵巢发育的影响。雌性大鼠在产后第 5 天接受柠檬酸盐缓冲液（对照 C）或链脲佐菌素（用于糖尿病诱导-D）。这些成年大鼠交配以获得来自对照母鼠（OC）或糖尿病母鼠（OD）的雌性幼崽（O），并在断奶后至成年期间接受标准饮食（SD）或高脂肪饮食（HFD），并分为 OC/SD、OC/HFD、OD/SD 和 OD/HFD。在成年期进行 OGTT 和 AUC。这些大鼠被麻醉并安乐死以收集样本。发现相当一部分糖尿病大鼠属于 OD/HFD 组（OD/HFD 40%比 OC/SD 0% < 0.05）。实验组的孕酮浓度较低（OC/HFD 0.40 ± 0.04；OD/SD 0.30 ± 0.03；OD/HFD 0.24 ± 0.04 比 OC/SD 0.45 ± 0.03 < 0.0001）。MFF 的表达较低（OD/SD 0.34 ± 0.33；OD/HFD 0.29 ± 0.2 比 OC/SD 1.0 ± 0.41 = 0.0015）和 MFN2 在 OD/SD 和 OD/HFD 组中（OD/SD 0.41 ± 0.21；OD/HFD 0.77 ± 0.18 比 OC/SD 1.0 ± 0.45 = 0.0037）。OD/SD 和 OD/HFD 组的卵泡数量较少。OC/HFD、OD/SD 和 OD/HFD 组的卵巢细胞中 SOD 和 Catalase 的染色强度较低，MDA 的染色强度较高。胎儿编程导致线粒体功能障碍、卵巢储备损失和氧化应激；母体糖尿病与高脂肪饮食的结合导致雌性幼鼠糖尿病的发生率更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b1/10609718/cf1a39df254a/nutrients-15-04407-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b1/10609718/cf1a39df254a/nutrients-15-04407-g007.jpg

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Diabetes Care. 2023 Jan 1;46(Suppl 1):S19-S40. doi: 10.2337/dc23-S002.
2
Maternal Diabetes and Postnatal High-Fat Diet on Pregnant Offspring.母体糖尿病与产后高脂饮食对怀孕子代的影响
Front Cell Dev Biol. 2022 May 30;10:818621. doi: 10.3389/fcell.2022.818621. eCollection 2022.
3
Is Type 2 Diabetes a Primary Mitochondrial Disorder?2型糖尿病是原发性线粒体疾病吗？
Cells. 2022 May 12;11(10):1617. doi: 10.3390/cells11101617.
4
Oxidative Stress Profile of Mothers and Their Offspring after Maternal Consumption of High-Fat Diet in Rodents: A Systematic Review and Meta-Analysis.母体高脂饮食后母亲及其后代的氧化应激特征：系统评价和荟萃分析。
Oxid Med Cell Longev. 2021 Nov 24;2021:9073859. doi: 10.1155/2021/9073859. eCollection 2021.
5
Proliferating cell nuclear antigen presentation, as a marker of folliculogenesis, in the transplanted ovarian tissue.移植卵巢组织中增殖细胞核抗原的呈现，作为卵泡发生的标志物。
J Obstet Gynaecol Res. 2021 Dec;47(12):4340-4349. doi: 10.1111/jog.15022. Epub 2021 Oct 22.
6
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