在阿尔茨海默病兔模型中，膳食胆固醇会增加心室容积并缩小脑血管直径。
Dietary cholesterol increases ventricular volume and narrows cerebrovascular diameter in a rabbit model of Alzheimer's disease.
作者信息
Schreurs B G, Smith-Bell C A, Lemieux S K
机构信息
Department of Physiology and Pharmacology, and the Blanchette Rockefeller Neurosciences Institute, West Virginia University, Morgantown, WV, United States.
出版信息
Neuroscience. 2013 Dec 19;254:61-9. doi: 10.1016/j.neuroscience.2013.09.015. Epub 2013 Sep 14.
Abstract
Using structural magnetic resonance imaging in a clinical scanner at 3.0T, we describe results showing that following 12weeks on a diet of 2% cholesterol, rabbits experience a significant increase in the volume of the third ventricle compared to rabbits on a diet of 0% cholesterol. Using time-of-flight magnetic resonance angiography, we find cholesterol-fed rabbits also experience a decrease in the diameter of a number of cerebral blood vessels including the basilar, posterior communicating, and internal carotid arteries. Taken together, these data confirm that, despite the inability of dietary cholesterol to cross the blood-brain barrier, it does significantly enlarge ventricular volume and decrease cerebrovascular diameter in the rabbit - effects that are also seen in patients with Alzheimer's disease.
摘要
在3.0T临床扫描仪上使用结构磁共振成像，我们描述的结果表明，与食用0%胆固醇饮食的兔子相比，食用2%胆固醇饮食12周后，兔子的第三脑室体积显著增加。使用时间飞跃磁共振血管造影，我们发现喂食胆固醇的兔子还出现了包括基底动脉、后交通动脉和颈内动脉在内的一些脑血管直径减小的情况。综合来看，这些数据证实，尽管膳食胆固醇无法穿过血脑屏障，但它确实会显著增大兔子的脑室体积并减小脑血管直径——阿尔茨海默病患者也会出现这些效应。
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