Li Hong-Wei, Zhang Ling, Qin Chuan
NHC Key Laboratory of Human Disease Comparative Medicine Peking Union Medical College (PUMC) Beijing China.
Key Laboratory of Human Diseases Animal Model State Administration of Traditional Chinese Medicine Peking Union Medical College (PUMC) Beijing China.
Animal Model Exp Med. 2019 Dec 9;2(4):227-238. doi: 10.1002/ame2.12092. eCollection 2019 Dec.
With the increasingly serious aging of the global population, dementia has already become a severe clinical challenge on a global scale. Dementia caused by Alzheimer's disease (AD) is the most common form of dementia observed in the elderly, but its pathogenetic mechanism has still not been fully elucidated. Furthermore, no effective treatment strategy has been developed to date, despite considerable efforts. This can be mainly attributed to the paucity of animal models of AD that are sufficiently similar to humans. Among the presently established animal models, non-human primates share the closest relationship with humans, and their neural anatomy and neurobiology share highly similar characteristics with those of humans. Thus, there is no doubt that these play an irreplaceable role in AD research. Considering this, the present literature on non-human primate models of AD was reviewed to provide a theoretical basis for future research.
随着全球人口老龄化日益严重，痴呆症已成为全球范围内严峻的临床挑战。阿尔茨海默病（AD）所致痴呆症是老年人中最常见的痴呆形式，但其发病机制仍未完全阐明。此外，尽管付出了巨大努力，但迄今为止尚未开发出有效的治疗策略。这主要归因于与人类足够相似的AD动物模型的匮乏。在目前已建立的动物模型中，非人灵长类动物与人类的关系最为密切，它们的神经解剖结构和神经生物学与人类具有高度相似的特征。因此，毫无疑问，这些在AD研究中发挥着不可替代的作用。鉴于此，本文对AD非人灵长类动物模型的相关文献进行综述，为未来的研究提供理论依据。
