Zhang Xifeng, Ji Jianfei, Liu Bo
Department of Orthopaedics, Chinese PLA General Hospital, Beijing, China.
J Int Med Res. 2013 Oct;41(5):1395-407. doi: 10.1177/0300060513498023. Epub 2013 Sep 17.
A systematic review and meta-analysis of randomized controlled trials (RCTs) studying the clinical benefit of chemotherapy with surgical intervention over chemotherapy alone for the treatment of spinal tuberculosis.
Relevant RCTs were identified by computerized database searches. Trial eligibility and methodological quality were assessed and data were extracted and analysed using odds ratios with 95% confidence intervals. The primary outcome measure was kyphosis angle.
The literature search identified two RCTs conducted in the 1970s and 1980s and a Cochrane Database Systematic Review published in 2006. There were no significant between-group differences in kyphosis angle, bony fusion, bone loss or development of neurological deficit.
There is no obvious statistically significant clinical precedence to suggest that routine surgery will improve the prognosis of patients with spinal tuberculosis.
对研究化疗联合手术干预与单纯化疗治疗脊柱结核的临床疗效的随机对照试验（RCT）进行系统评价和荟萃分析。
通过计算机数据库检索确定相关的随机对照试验。评估试验的纳入标准和方法学质量，并使用95%置信区间的比值比提取和分析数据。主要结局指标为后凸角。
文献检索发现了20世纪70年代和80年代进行的两项随机对照试验以及2006年发表的一篇Cochrane系统评价。在后凸角、骨融合、骨质流失或神经功能缺损的发生方面，组间无显著差异。
没有明显的统计学显著临床证据表明常规手术会改善脊柱结核患者的预后。
