Tait R G, Downey E D, Mayes M S, Park C A, Ridpath J F, Garrick D J, Reecy J M
Department of Animal Science, Iowa State University, Ames 50011.
J Anim Sci. 2013 Nov;91(11):5466-76. doi: 10.2527/jas.2012-5891. Epub 2013 Sep 17.
There are concerns about antagonisms between immunity and animal productivity in livestock production. The objective of this study was to evaluate the effect of antibody levels through a response to vaccination protocol, weaning timing, and their interaction on performance and carcass quality traits in Angus beef cattle. Final antibody level and response to vaccination were based on neutralizing serum antibodies against bovine viral diarrhea virus type 2 (BVDV2). Calves were followed through development and the feedlot phase, with collection of yearling ultrasound (n=957), preharvest (n=762), and carcass (n=673) data. In this study, 48% of the animals were observed to have positively responded to the vaccine, as evidenced by higher final antibody levels compared to prevaccination antibody levels. Increased final antibody levels were significantly (P<0.05) associated with increased yearling weight and increased subcutaneous fat over the rump. An interaction between final antibody level and weaning time also was associated (P<0.05) with Warner-Bratzler shear force (WBSF) and meat pH, with a favorable, negative relationship between final antibody and WBSF in calves weaned at initial vaccination. Overall antibody response by wean time interaction had a significant (P<0.05) association with ADG and meat pH, with calves weaned at initial vaccination having a favorable, positive relationship between overall antibody response and ADG. Under both the final antibody and overall antibody response models, animals weaned at initial vaccination had significantly (P<0.05) lower intramuscular fat at yearling time and conversely higher harvest weight than animals weaned at the booster vaccination. When antibody response was grouped (none, low, high), a significant interaction (P<0.05) between antibody response group and weaning time was identified for ADG, harvest weight, and HCW. Animals weaned at the initial vaccination in the high antibody response group had the advantage for ADG, harvest weight, and HCW compared to animals in the high-response group that were weaned at booster vaccination. Linear increases in antibody response generally did not have negative effects on performance or carcass quality traits in finished cattle (P>0.05). Therefore, producers should not be concerned about decreased production or quality attributes as a result of developing a robust antibody response to vaccination for BVDV2 in beef cattle.
在畜牧生产中,人们担心免疫力与动物生产力之间存在拮抗作用。本研究的目的是通过对疫苗接种方案、断奶时间及其相互作用的反应来评估抗体水平对安格斯肉牛生产性能和胴体品质性状的影响。最终抗体水平和对疫苗接种的反应基于针对2型牛病毒性腹泻病毒(BVDV2)的中和血清抗体。对犊牛从发育阶段到育肥阶段进行跟踪,收集一岁时超声数据(n = 957)、屠宰前数据(n = 762)和胴体数据(n = 673)。在本研究中,观察到48%的动物对疫苗有阳性反应,与接种前抗体水平相比,最终抗体水平更高即证明了这一点。最终抗体水平升高与一岁体重增加和臀部皮下脂肪增加显著相关(P<0.05)。最终抗体水平与断奶时间之间的相互作用也与沃纳-布拉茨勒剪切力(WBSF)和肉的pH值相关(P<0.05),在初次接种疫苗时断奶的犊牛中,最终抗体与WBSF呈有利的负相关关系。按断奶时间相互作用的总体抗体反应与平均日增重(ADG)和肉的pH值显著相关(P<0.05),在初次接种疫苗时断奶的犊牛中,总体抗体反应与ADG呈有利的正相关关系。在最终抗体和总体抗体反应模型下,初次接种疫苗时断奶的动物在一岁时的肌内脂肪显著低于(P<0.05)在加强免疫接种时断奶的动物,相反,其屠宰体重更高。当将抗体反应分组(无、低、高)时,在ADG、屠宰体重和热胴体重方面,抗体反应组与断奶时间之间存在显著的相互作用(P<0.05)。与在加强免疫接种时断奶的高反应组动物相比,高抗体反应组中在初次接种疫苗时断奶的动物在ADG、屠宰体重和热胴体重方面具有优势。抗体反应的线性增加通常对育肥牛的生产性能或胴体品质性状没有负面影响(P>0.05)。因此,生产者不应担心肉牛因对BVDV2疫苗接种产生强烈抗体反应而导致生产或品质属性下降。