Fallahi P, Ferrari S M, Giuggioli D, Corrado A, Fabiani S, Marchi S, Ferri C, Antonelli A
Departments of Clinical and Experimental Medicine, University of Pisa, Pisa.
Clin Ter. 2013;164(4):e337-41. doi: 10.7417/CT.2013.1598.
In patients with hepatitis C virus-associated mixed cryoglobulinemia (MC+HCV) the following thyroid disorders are significantly more frequent than in HCV not infected controls: 1) high levels of serum anti-thyroperoxidase autoantibody (AbTPO), 2) high levels of serum AbTPO and/or anti-thyroglobulin (AbTg) autoantibody; 3) humoral and ultrasonographical signs of thyroid autoimmunity (35%); 4) prevalence of subclinical hypothyroidism (11%). Also, the prevalence of papillary thyroid cancer has been found higher in MC+HCV patients than in controls, in particular in patients with autoimmune thyroiditis. These results suggest a careful monitoring of thyroid function in these patients.
在丙型肝炎病毒相关混合性冷球蛋白血症（MC+HCV）患者中，以下甲状腺疾病的发生率显著高于未感染HCV的对照组：1）血清抗甲状腺过氧化物酶自身抗体（AbTPO）水平升高；2）血清AbTPO和/或抗甲状腺球蛋白（AbTg）自身抗体水平升高；3）甲状腺自身免疫的体液和超声征象（35%）；4）亚临床甲状腺功能减退的患病率（11%）。此外，MC+HCV患者中甲状腺乳头状癌的患病率高于对照组，尤其是自身免疫性甲状腺炎患者。这些结果表明应对这些患者的甲状腺功能进行仔细监测。
