Radin A I
Hematology Section, Yale University School of Medicine, New Haven, CT 06510.
Cancer. 1990 Feb 1;65(3):550-63. doi: 10.1002/1097-0142(19900201)65:3<550::aid-cncr2820650328>3.0.co;2-w.
Primary pulmonary Hodgkin's disease is a rare but distinct entity, to be distinguished from nodal Hodgkin's disease and from lymphomas involving the lung secondarily. Sixty-one cases have now been reported in the world's literature. This lymphoma affects women more frequently than men, and typically involves the superior portions of the lungs. Radiologically, it appears as a solitary mass or multinodular disease; inhomogeneity or cavitation of these lesions are common. Since the presentation of this disease is nonspecific, and as noninvasive tests are rarely revealing, diagnosis requires an open thoracotomy and lung biopsy. Factors which correlate with a poorer prognosis include "B" symptoms, bilateral disease, multilobe involvement, penetration of the pleura, and cavitation. The staging and treatment of these lymphomas according to the extent of pulmonary involvement are recommended, as radiotherapy or combination chemotherapy may be effective in appropriately selected patients.
原发性肺霍奇金病是一种罕见但独特的疾病，需与结节性霍奇金病以及继发累及肺部的淋巴瘤相鉴别。目前世界文献已报道61例。这种淋巴瘤女性比男性更易受累，且通常累及肺上部。放射学上，表现为孤立性肿块或多结节病变；这些病变的不均匀性或空洞形成很常见。由于该病表现不具特异性，且非侵入性检查很少能明确诊断，因此诊断需要开胸肺活检。与预后较差相关的因素包括“B”症状、双侧病变、多叶受累、胸膜侵犯和空洞形成。建议根据肺部受累程度对这些淋巴瘤进行分期和治疗，因为放疗或联合化疗对适当选择的患者可能有效。
