Division of Weight Management and Wellness and.
Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1222-9. doi: 10.1152/ajpendo.00285.2013. Epub 2013 Sep 17.
It is unclear whether regular exercise alone (no caloric restriction) is a useful strategy to reduce adiposity and obesity-related metabolic risk factors in obese girls. We examined the effects of aerobic (AE) vs. resistance exercise (RE) alone on visceral adipose tissue (VAT), intrahepatic lipid, and insulin sensitivity in obese girls. Forty-four obese adolescent girls (BMI ≥95th percentile, 12-18 yr) with abdominal obesity (waist circumference 106.5 ± 11.1 cm) were randomized to 3 mo of 180 min/wk AE (n = 16) or RE (n = 16) or a nonexercising control group (n = 12). Total fat and VAT were assessed by MRI and intrahepatic lipid by proton magnetic resonance spectroscopy. Intermuscular AT (IMAT) was measured by CT. Insulin sensitivity was evaluated by a 3-h hyperinsulinemic (80 mU·m(2)·min(-1)) euglycemic clamp. Compared with controls (0.13 ± 1.10 kg), body weight did not change (P > 0.1) in the AE (-1.31 ± 1.43 kg) and RE (-0.31 ± 1.38 kg) groups. Despite the absence of weight loss, total body fat (%) and IMAT decreased (P < 0.05) in both exercise groups compared with control. Compared with control, significant (P < 0.05) reductions in VAT (Δ-15.68 ± 7.64 cm(2)) and intrahepatic lipid (Δ-1.70 ± 0.74%) and improvement in insulin sensitivity (Δ0.92 ± 0.27 mg·kg(-1)·min(-1) per μU/ml) were observed in the AE group but not the RE group. Improvements in insulin sensitivity in the AE group were associated with the reductions in total AT mass (r = -0.65, P = 0.02). In obese adolescent girls, AE but not RE is effective in reducing liver fat and visceral adiposity and improving insulin sensitivity independent of weight loss or calorie restriction.
单独进行常规运动（不限制热量）是否是减少肥胖女孩体脂肪和肥胖相关代谢风险因素的有效策略尚不清楚。我们研究了有氧运动（AE）与抗阻运动（RE）单独对肥胖女孩内脏脂肪组织（VAT）、肝内脂肪和胰岛素敏感性的影响。44 名肥胖青少年女孩（BMI≥95 百分位，12-18 岁）存在腹型肥胖（腰围 106.5±11.1cm），随机分为 3 个月的 180 分钟/周 AE（n=16）或 RE（n=16）或不运动对照组（n=12）。通过 MRI 评估总脂肪和 VAT，通过质子磁共振波谱评估肝内脂肪。通过 CT 测量肌间脂肪（IMAT）。通过 3 小时高胰岛素（80mU·m2·min-1）正葡萄糖钳夹评估胰岛素敏感性。与对照组（0.13±1.10kg）相比，AE（-1.31±1.43kg）和 RE（-0.31±1.38kg）组体重无变化（P＞0.1）。尽管体重未减轻，但与对照组相比，两组运动者的总体脂肪（%）和 IMAT 均降低（P＜0.05）。与对照组相比，AE 组的 VAT（Δ-15.68±7.64cm2）和肝内脂肪（Δ-1.70±0.74%）显著减少（P＜0.05），胰岛素敏感性改善（Δ0.92±0.27mg·kg-1·min-1·μU/ml），RE 组无变化。AE 组胰岛素敏感性的改善与总脂肪质量的减少相关（r=-0.65，P=0.02）。在肥胖青少年女孩中，AE 而非 RE 可有效减少肝脏脂肪和内脏脂肪堆积，改善胰岛素敏感性，且不依赖于体重减轻或热量限制。
