Seitz Helmut, Pichl Wofgang, Matzi Veronika, Nau Thomas
Department of Trauma Surgery, Medical University of Graz, Auenbruggerplatz, Graz, Austria.
Int Orthop. 2013 Nov;37(11):2305-11. doi: 10.1007/s00264-013-2098-8. Epub 2013 Sep 18.
The purpose of this study was to evaluate in a sheep model the biomechanical performance of augmented and nonaugmented primary repair of the anterior cruciate ligament (ACL) following transection at the femoral end during a 12-month postoperative observation.
Forty sheep were randomly assigned to nonaugmented or augmented primary ACL repair using a polyethylene terephthalate (PET) band. At two, six, 16, 26 and 52 weeks postoperatively four sheep in each group were sacrificed and biomechanical testing performed.
Compared with nonaugmented primary ACL repair, the PET-augmented repair demonstrated superior biomechanical results from 16 weeks postoperatively onwards in terms of anterioposterior (AP) laxity, tensile strength and ligament stiffness. The augmentation device works as a stress shield during the ligament healing process. The nonaugmented ACL repair also resulted in ligament healing, but the biomechanical properties were at a significantly lower level.
These results support the previously reported histological findings following augmented primary ACL repair. This animal study on the healing capacity of the ACL may provide some important contributions to how primary healing in certain types of ruptures can be achieved.
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本研究旨在通过绵羊模型，评估在术后12个月的观察期内，股骨端横断后前交叉韧带（ACL）增强修复与非增强一期修复的生物力学性能。
40只绵羊被随机分为两组，分别接受使用聚对苯二甲酸乙二酯（PET）带进行的非增强或增强一期ACL修复。术后2周、6周、16周、26周和52周时，每组处死4只绵羊并进行生物力学测试。
与非增强一期ACL修复相比，PET增强修复从术后16周起在前后（AP）松弛度、拉伸强度和韧带刚度方面显示出更好的生物力学结果。增强装置在韧带愈合过程中起到应力屏蔽的作用。非增强ACL修复也实现了韧带愈合，但其生物力学性能显著较低。
这些结果支持了先前报道的ACL增强一期修复后的组织学研究结果。这项关于ACL愈合能力的动物研究可能为如何实现某些类型断裂的一期愈合提供一些重要参考。
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