基于碱催化的 3-异硫氰酸酯氧吲哚和亚胺的立体选择性[3 + 3]环加成反应。

Base-catalyzed diastereoselective [3 + 3] annulation of 3-isothiocyanatooxindoles and azomethine imines.

机构信息

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, P.R. China.

出版信息

Org Lett. 2013 Oct 4;15(19):4988-91. doi: 10.1021/ol402295m. Epub 2013 Sep 18.

DOI:10.1021/ol402295m

PMID:24047279

Abstract

An unprecedented diastereoselective [3 + 3] annulation of 3-isothiocyanatooxindoles and azomethine imines was catalyzed by Et3N, affording 3,3'-triazinyl spirooxindoles in excellent yields and diastereoselectivities under mild conditions.

摘要

三乙胺催化 3-异硫氰酸酯基氧化吲哚与亚胺的首例非对映选择性[3 + 3]环加成反应，在温和条件下以优异的收率和非对映选择性得到了 3,3'-三嗪基螺氧化吲哚。