血红蛋白低伴铁蛋白低：这不仅仅是贫血问题。
Lower hemoglobin with lower ferritin: It is not just a question of anemia.
机构信息
Department of Clinical Chemistry, Trondheim University Hospital , Trondheim , Norway.
出版信息
Scand J Clin Lab Invest. 2013 Dec;73(8):622-6. doi: 10.3109/00365513.2013.835863. Epub 2013 Sep 19.
AIM
To study the association between blood hemoglobin concentration (b-hemoglobin) and serum ferritin concentration (s-ferritin) in an ambulant patient population without inflammation and with normal kidney function.
METHODS
In ambulant, adult patients with normal values of s-CRP and s-creatinine, median b-hemoglobin and the fraction with anemia was compared in groups with lower s-ferritin from a level of 100 μg/L. The 10, 50 and 90 percentiles of b-hemoglobin were modelled as functions of s-ferritin using quantile regression.
RESULTS
Among 3206 women the entire b-hemoglobin distribution was shifted downwards in patients with s-ferritin less than 20 μg/L. Accordingly, the median b-hemoglobin was statistically significantly lower and the fraction with anemia was higher. In 1246 men the findings were similar, except that the turning point toward lower b-hemoglobin was at a s-ferritin level of 30 μg/L.
CONCLUSIONS
Low s-ferritin is associated with decreased b-hemoglobin in many more subjects than those labelled anemic.
目的
研究无炎症和正常肾功能的门诊患者人群中血血红蛋白浓度（b-hemoglobin）与血清铁蛋白浓度（s-ferritin）之间的关联。
方法
在门诊成年患者中，s-CRP 和 s-肌酐值正常，将 s-ferritin 水平低于 100μg/L 的患者分为低 s-ferritin 组，比较组间中位 b-hemoglobin 和贫血发生率。采用分位数回归对 b-hemoglobin 的第 10、50 和 90 百分位数与 s-ferritin 进行建模。
结果
在 3206 名女性中，s-ferritin<20μg/L 的患者整个 b-hemoglobin 分布均向下偏移。相应地，b-hemoglobin 中位数显著降低，贫血发生率升高。在 1246 名男性中，结果类似，但 b-hemoglobin 下降的转折点出现在 s-ferritin 水平为 30μg/L。
结论
与贫血患者相比，低 s-ferritin 与更多患者的 b-hemoglobin 降低有关。
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