Departments of *Neuroscience and †Medicine, Georgetown University Medical Center, Washington, DC; ‡Departments of Medicine and Epidemiology & Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY; §Departments of Medicine, Stroger Hospital and Rush University, Chicago, IL; ‖Departments of Neurology and Pathology, SUNY Downstate Medical Center, Brooklyn, NY; ¶Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA; #Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Departments of **Neurology; ††Biostatistics, Bioinformatics, and Biomathematics; ‡‡Psychiatry, Georgetown University Medical Center, Washington, DC; and §§Collaborative for Research on Outcomes and Metrics, Department of Neurology, Georgetown University Medical Center, Washington, DC.
J Acquir Immune Defic Syndr. 2013 Oct 1;64(2):138-41. doi: 10.1097/QAI.0b013e3182a468e9.
Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 (rs2072446) were associated with depression in HIV-infected individuals. A total of 1365 HIV-positive and 371 HIV-negative female subjects were included. The distribution of alleles was analyzed independently in African Americans (non-Hispanic) and Caucasians (non-Hispanic). We have found that the absence of depressive symptoms in HIV-positive subjects is associated with a genetic variation of the TrkB but not with BDNF or p75 genes. This mutation explains 0.8% and 4.4% of the variability for the absence of depression in African Americans and Caucasians, respectively.
感染 HIV 1 型的个体比未感染的个体更容易患上抑郁症。HIV 降低了脑源性神经营养因子（BDNF），BDNF 是一种神经营养因子，其受体在抑郁症的病理生理学中起着至关重要的作用。因此，我们研究了 BDNF 基因（rs56164415）和相关受体 TrkB（rs1212171）和 p75（rs2072446）中的单个核苷酸多态性是否与 HIV 感染者的抑郁症有关。共有 1365 名 HIV 阳性和 371 名 HIV 阴性的女性受试者被纳入研究。在非西班牙裔的非洲裔美国人和白种人中分别独立分析等位基因的分布。我们发现，HIV 阳性受试者没有抑郁症状与 TrkB 的遗传变异有关，但与 BDNF 或 p75 基因无关。这种突变分别解释了非西班牙裔的非洲裔美国人和白种人没有抑郁的 0.8%和 4.4%的可变性。
