Yang Jianmin, Siao Chia-Jen, Nagappan Guhan, Marinic Tina, Jing Deqiang, McGrath Kelly, Chen Zhe-Yu, Mark Willie, Tessarollo Lino, Lee Francis S, Lu Bai, Hempstead Barbara L
Department of Medicine, Weill Cornell Medical College, 1300 York Ave., New York, New York 10065, USA.
Nat Neurosci. 2009 Feb;12(2):113-5. doi: 10.1038/nn.2244. Epub 2009 Jan 11.
Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in adulthood. Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB.
脑源性神经营养因子前体（proBDNF）和成熟BDNF利用不同的受体介导不同的神经元作用。通过使用新工具定量内源性BDNF异构体，我们发现小鼠神经元分泌proBDNF和成熟BDNF。出生时观察到proBDNF和p75的水平最高，成年后下降，但仍可检测到。因此，BDNF的作用在发育过程中受到proBDNF或成熟BDNF的分泌以及p75和TrkB局部表达的调节。
