Emerg Infect Dis. 2013 Oct;19(10):1612-9. doi: 10.3201/eid1910.121836.
In a previous cross-sectional study, we showed that clinical staff working in a hospital had significantly higher antibody levels than nonclinical staff to Pneumocystis jirovecii. We conducted a longitudinal study, described here, to determine whether occupation and self-reported exposure to a patient with P. jirovecii pneumonia were associated with antibody levels to P. jirovecii over time. Baseline and quarterly serum specimens were collected and analyzed by using an ELISA that targeted different variants of the Pneumocystis major surface glycoprotein (MsgA, MsgB, MsgC1, MsgC3, MsgC8, and MsgC9). Clinical staff had significantly higher estimated geometric mean antibody levels against MsgC1 and MsgC8 than did nonclinical staff over time. Significant differences were observed when we compared the change in antibody levels to the different MsgC variants for staff who were and were not exposed to P. jirovecii pneumonia-infected patients. MsgC variants may serve as indicators of exposure to P. jirovecii in immunocompetent persons.
在之前的一项横断面研究中，我们发现医院临床工作人员针对耶氏肺孢子菌的抗体水平明显高于非临床工作人员。我们进行了一项纵向研究，描述如下，以确定职业和自我报告的耶氏肺孢子菌肺炎患者接触与耶氏肺孢子菌抗体水平随时间的变化是否相关。采集并分析了基线和每季度的血清标本，使用的 ELISA 针对不同变体的肺孢子菌主要表面糖蛋白（MsgA、MsgB、MsgC1、MsgC3、MsgC8 和 MsgC9）。随着时间的推移，临床工作人员针对 MsgC1 和 MsgC8 的估计几何平均抗体水平明显高于非临床工作人员。当我们比较接触和未接触耶氏肺孢子菌肺炎感染患者的工作人员对不同 MsgC 变体的抗体水平变化时，观察到了显著差异。MsgC 变体可能是免疫功能正常者接触耶氏肺孢子菌的指标。
